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Senior Scientist Upstream Early Pipeline Development Job

Senior Scientist Upstream Early Pipeline Development Job at Novartis Pharma Company. Interested Candidate Can Apply For This Position

Senior Scientist Upstream Early Pipeline Development Job
Senior Scientist Upstream Early Pipeline Development Job





San Diego, California, United States



Position Type

Full Time

Job Type

Senior Scientist

Organization Type


Closing date

29 May 2023

Job Description for Senior Scientist Upstream Early Pipeline Development Job

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. As a Senior Scientist, you will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.

We are seeking a Senior Scientist in supporting early-stage recombinant adenovirus-associated virus (rAAV) gene therapy pipeline portfolio with the focus on manufacture developability and building improved process technologies for rAAV manufacture. This role is also responsible for executing early-stage process development for existing and novel engineered cell lines, AAV capsids and cargo vectors.

Responsibilities For This Job

• Execute adherent and suspension small-scale bioreactor-based cell culture processes for manufacturing of AAV gene therapy vectors across multiple preclinical programs and disease areas to ensure on time delivery.
• Engage collaboratively in operational and strategic discussion within a global team.
• Design and execute experiments to drive innovative technology and platform evaluation for next generation capsids and cargo vectors and work collaboratively with downstream process development and analytical development teams.
• Serve as interface with downstream, Disease Areas and platform/technology teams to drive early drug discovery from target selection and validation through lead compound selection and developability assessment
• Serve as an interface to transfer knowledge and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
• Provide technical support, training, and SME knowledge to assist with the development of junior associates.
• Prepare protocols, reports and provide high quality data and electronic notebook documentation.
• Other related job duties as assigned.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What You'll Bring to the Role:

• B.S. biology, biochemical engineering, bioprocessing, pharmaceutical sciences, or related technical field. Master’s degree preferred.
• Industry experience is required.
• Prior experiences developing novel upstream process for recombinant proteins and antibodies or early-stage AAV or other viral vector manufacturing and/or process development is required.
• Experience in operating adherent cell culture bioreactor, microbioreactor (e.g. ambr) and single-use small scale (up to 50L) stirred-tank bioreactor experiments for mammalian cell culture.
• Design of experiments (DoE)
• Effective communication including presentations to convey scientific concepts to research scientists and cross-functional collaborators.
• Strong team player who demonstrates technical proficiency and creativity, collaboration with others and independent thought. Ability to work in a matrix environment.
• Strong organization, analytical, and problem-solving skills with attention to details.

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

The pay range for this position at commencement of employment is expected to be between $102,400 to $153,600/year; however, while salary ranges are effective from 1/1/22 through 12/31/22, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

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